Abstract
BackgroundThe role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulation product and liver fat assessed by fatty liver index to the risk of hyperuricemia.MethodsWe conducted a cross-sectional study involving 1284 participants aged ≥ 40 years old recruited from communities in Zhonglou district, Changzhou. Each participant completed a standard questionnaire, and provided blood samples for biochemical measurements. Visceral adiposity index, fatty liver index and lipid accumulation product were calculated by simple anthropometric and functional parameters. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/l for males and ≥ 360 μmol/l for females.ResultsThe prevalence of hyperuricemia was 15.9% and gradually increased across tertiles of adiposity-based indices. The visceral adipose-based measurements (visceral adiposity index, fatty liver index, lipid accumulation product) had better power to discriminate hyperuricemia than body mass index (BMI), waist circumference and neck circumference, and visceral adiposity index exhibited the highest power, with the area under the receiver operating characteristics curve (AUROC) of 0.662 (0.636–0.688). Multivariate logistic regression found 1.49-fold, 2.21-fold and 2.12-fold increased risk of hyperuricemia with 1-unit increment of visceral adiposity index, fatty liver index, and lipid accumulation product, respectively. Compared to tertile 1, the odds ratios of hyperuricemia for the second tertile and the third tertile of visceral adiposity index were 1.57 (1.00–2.50) and 3.11 (1.96–4.94), those of fatty liver index were 1.64 (1.05–2.68) and 3.58 (1.94–6.01), and those of lipid accumulation product were 1.93 (1.19–3.15) and 3.53 (2.05–6.09), respectively. However, no significant associations of BMI, waist circumference and neck circumference with hyperuricemia were observed.ConclusionsVisceral adipose accumulation increased the risk of hyperuricemia, independently of BMI, waist circumference and neck circumference, among middle-aged and elderly Chinese adults.
Highlights
The role of body fat distribution in uric acid metabolism is still ambiguity
Data were presented as mean ± standard deviation (SD) for median for continuous variables, and numbers for categorical variables P values were calculated by t test for continuous variables and Chi-square test for categorical variables activity, Systolic blood pressure (SBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), Fasting plasma glucose (FPG), alanine aminotransferase (ALT) or aspartate aminotransferase (AST)
Among adiposity-based measurements, levels of body mass index (BMI), waist circumference, visceral adiposity index, fatty liver index and lipid accumulation product were higher in individuals with hyperuricemia, compared to those without hyperuricemia
Summary
The role of body fat distribution in uric acid metabolism is still ambiguity. Growing evidence has showed that obesity or excess body fat mass was a risk factor of hyperuricemia [6, 7], the role of body fat distribution in uric acid metabolism is still ambiguity. Previous studies showed that changes of traditional adiposity-based indices, such as body mass index (BMI), waist circumference, neck circumference, were related to the changes of serum uric acid [8,9,10], demonstrating general obesity or central obesity significantly influenced serum uric acid metabolism. Two recent studies found that visceral fat or liver fat or both were significantly associated with hyperuricemia adjusting for BMI and waist circumference, independent of obesity phenotypes [14, 15]. Does the visceral adipose accumulation have more contribution to the progress of hyperuricemia than adipose deposited in other parts of the body?
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