Abstract
Virtual Screening of Indonesian Herbal Database as alpha-Amino-3- Hydroxy-5-Methyl-4 Isoxazolepropionic Acid (AMPA) Antagonist
Highlights
In 2012, WHO reported about 6.7 million deaths in this world caused by stroke.[1]
This study aims to explore the possibility of an Indonesian herbal compound as an Amino-3-Hydroxy-5-Methyl-4 Isoxazolepropionic Acid (AMPA) receptor antagonist
Since the actives and decoys of this research were from Directory of Useful DecoysEnhanced (DUD-E), the area under curve (AUC) and enrichment factor (EF) of DUD-E were considered
Summary
In 2012, WHO reported about 6.7 million deaths in this world caused by stroke.[1]. And it was expected to rise to 23.3 million deaths by 2030.2 Stroke was a cardiovascular disease caused by blood supply disruption to the brain due to rupture of blood vessels (hemorrhagic) or blockage of blood vessels (ischemic). An ischemic stroke, which caused by a blood clot that blocks blood flow to the brain, more frequent which amounted to 87% of all strokes.[3]. The previous study reported that stroke disability rate reaches 65%.4. Disability occurs because the brain's nerve cells were susceptible to the lack of oxygen, leads to the cerebral hypoxia. ROS levels were increased and cause the degradation of lipid membranes and enzymes as well as DNA damage. Damage to nerve cells that occur is irreversible. It takes a neuroprotective agent to protect brain nerve cells from damage.[5] During this time, neurologic complications of ischemic stroke were overcome by administration of anticonvulsant agents.[6]
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