Abstract
A proteome-wide study of the virus kingdom based on 1.713 million protein sequences from 19,128 virus proteomes was conducted to construct an overall proteome map of the virus kingdom. Viral proteomes encode an average of 386.214 amino acids per protein with the variation in the number of protein-coding sequences being host-specific. The proteomes of viruses of fungi hosts (882.464) encoded the greatest number of amino acids, while the viral proteome of bacterial host (210.912) encoded the smallest number of amino acids. Viral proteomes were found to have a host-specific amino acid composition. Leu (8.556%) was the most abundant and Trp (1.274%) the least abundant amino acid in the collective proteome of viruses. Viruses were found to exhibit a host-dependent molecular weight and isoelectric point of encoded proteins. The isoelectric point (pI) of viral proteins was found in the acidic range, having an average pI of 6.89. However, the pI of viral proteins of algal (pI 7.08) and vertebrate (pI 7.09) hosts was in the basic range. The virtual 2D map of the viral proteome from different hosts exhibited host-dependent modalities. The virus proteome from algal hosts and archaea exhibited a bimodal distribution of molecular weight and pI, while the virus proteome of bacterial host exhibited a trimodal distribution, and the virus proteome of fungal, human, land plants, invertebrate, protozoa, and vertebrate hosts exhibited a unimodal distribution.
Highlights
A proteome-wide study of the virus kingdom based on 1.713 million protein sequences from 19,128 virus proteomes was conducted to construct an overall proteome map of the virus kingdom
Viral genomes with complete protein annotation were utilized in the present analysis
Results of the analysis indicated that the molecular weight of viral proteins in human, invertebrate, land plants, protozoa, and vertebrate hosts were positively correlated (Fig. 5)
Summary
A proteome-wide study of the virus kingdom based on 1.713 million protein sequences from 19,128 virus proteomes was conducted to construct an overall proteome map of the virus kingdom. Viral proteomes encode an average of 386.214 amino acids per protein with the variation in the number of protein-coding sequences being host-specific. Viral proteomes were found to have a host-specific amino acid composition. Viral genomes have been widely used to better understand the process of gene and DNA replication, transcription, RNA formation, translation, protein formation, and immunology[19]. The genomic aspects of viruses are frequently studies, the proteome of viruses is poorly understood Viral genomes, their role in immune modulation, and the use of viral genomes in vaccine development have gained enormous attention. When viruses lack either conserved DNA or protein consensus sequences, it becomes essential to analyse viral genomes and proteins as they relate to host specificity. We conducted a proteome-wide analysis of the proteome of the virus kingdom to provide details pertaining to the composition and structure of the proteome of the virus kingdom
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
