Abstract
In the last five years, cellular mRNA export has been extensively studied and revealed the existence of two distinct pathways. The majority of mRNA is exported in a TAP dependent pathway and the others RNAs need a CRM1 dependent pathway to reach the cytoplasm. During evolution, viruses acquired sophisticated mechanisms to hijack cellular pathways to export their genomic, subgenomic and messenger RNAs. Some viral nucleic acids code proteins that interact with the cellular export machinery and with viral RNAs. Others harbour specific secondary structures, which are recognized directly or indirectly by CRM-1 or TAP proteins. This review highlights these mechanisms, underlining the importance of virology in understanding the export of these cellular molecules from the nucleus.
Published Version
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