Virilization persists in a woman with an androgen-secreting granulosa cell tumor

Abstract

To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. Case report. University medical center. A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. Exploratory laparotomy with full staging. Surgical findings and histopathologic observations are included in this report. Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.