Abstract
Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. We report here a unique case of a 78-year Caucasian with a left sided adult type granulosa cell tumor with a heterologous sarcomatous tumor component. A heterologous sarcomatous component has occasionally been observed in ovarian tumors but never in testicular granulosa cell tumors. The sarcomatous component showed a higher number of mitotic figures (1/Hpf) and a marked proliferation rate (up to 50% Ki 67 positive cells) compared with the granulosa type tumor component. CD 99 and the progesterone receptor were positive in both tumor components, inhibin and calretinin only in the granulosa cells, and pancytokeratin only in the sarcomatouse one. Key words: testis - ovary - granulosa cells - sarcoma - inhibin Runing title: testicular sarcomatous granulosa tumor.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6959043481207016
Highlights
Tumors of sex cord/gonadal stroma are exceedingly rare tumors that, in large series, account for 1.6–6% of adult testicular tumors and occur somewhat more frequently in children [1]
Since the FOXL2 402C → G (C134W) mutation is present in adult-type granulosa cell tumors occurring in men, in a smaller proportion when compared with the rates reported in women [36], we performed this mutation analysis
CD 99 is consistently expressed, whereas EMA has never been detected in the different types of sex cord/gonadal stroma tumors of the testis; these antibodies are useful for the differential diagnosis stromal tumor vs. carcinoma metastasis [20,31,40]
Summary
Tumors of sex cord/gonadal stroma are exceedingly rare tumors that, in large series, account for 1.6–6% of adult testicular tumors and occur somewhat more frequently in children [1]. Since the FOXL2 402C → G (C134W) mutation is present in adult-type granulosa cell tumors occurring in men, in a smaller proportion when compared with the rates reported in women [36], we performed this mutation analysis. To this end, DNA of the tumor cells was extracted from serial sections (FFPE tissue) after manual microdissection using the Maxwell 16 System (Promega GmbH, Mannheim, Germany) in accordance with manufacturer’s instructions.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
