Abstract
Viral gastroenteritis is an important global problem that is being actively investigated. This year, stimulating new concepts regarding pathogenesis and immunity of the major viral pathogen of the gastrointestinal tract, rotavirus, were reported. In addition, highly promising results from phase 3 viral vaccine trials suggest that an effective vaccine for rotavirus will be available in the next several years. The range and diversity of human caliciviruses continues to be defined as more isolates are characterized. The ability to produce recombinant virus-like particles of human caliciviruses has enhanced diagnostic capability and enabled more extensive epidemiologic studies. The roles that human astrovirus, adenovirus, and newer agents, such as Aichi virus, play in diarrheal disease continue to be investigated.
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