Abstract
Background: Harlequin ichthyosis is a rare and fatal fetal disorder, most often complicated by infection. Sepsis due to Vibrio cholerae is rare, especially in neonatology. The association between ichthyosis and Vibrio cholerae infection has never been described in medical literature. Introduction: We report the case of a newborn admitted to the neonatal intensive care unit, with a typical characteristics of Harlequin ichthyosis and a sepsis due to Vibrio cholerae, diagnosed with the blood culture. The outcome was fatal; characterized by death six hours after his hospitalization. Conclusion: Cases of Harlequin ichthyosis complicated with septicemia with Pseudomonas Aeruginosa have been described. Vibrio cholerae infections are usually confined to the gastrointestinal tract but some species, especially non-01 strains, can cause extra-intestinal infections including septicemia and meningitis.
Highlights
We report the case of a newborn admitted to the neonatal intensive care unit, with a typical characteristics of Harlequin ichthyosis and a sepsis due to Vibrio cholerae, diagnosed with the blood culture
We report an exceptional case, never before reported in medical literature, of Vibrio cholerae sepsis in a neonate associated with Harlequin ichthyosis, admitted to the neonatal intensive care unit
The newborn was traited by triple antibiotic therapy (in the first the antibiotics was probabilistic for all neonatal infection in our unit; we used 3rd generation Cephalosporin and Aminoglycoside; in addition, in this case Metronidazole because the newborn had a fetid lesions) and topical Vaseline for local application
Summary
Harlequin ichthyosis is a rare and fatal fetal disorder, most often complicated by infection. Sepsis due to Vibrio cholerae is rare, especially in neonatology. The association between ichthyosis and Vibrio cholerae infection has never been described in medical literature
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