Abstract
AimThis study aims to examine the toxicity of collagen extracted from gouramy fish scales (Oshpronemus gouramy) by evaluating its viability against baby hamster kidney fibroblasts-21.Materials and MethodsCollagen was extracted from gouramy fish scales (O. gouramy) with 6% acetic acid. Its results were analyzed using Fourier-transform infrared spectroscopy and freeze-dried technique. Its morphology then was analyzed with scanning electron microscope. Afterward, 3-(4.5-dimethylthiazole-2-yl)2.5-diphenyl tetrazolium bromide assay was conducted to compare cells with and without fish scale collagen treatment.ResultsCollagen extracted from gouramy fish scales had no influence statistically on cultured fibroblast cells with a statistical significance (2-tailed) value of0.754 (p>00025).ConclusionCollagen extracted from gouramy fish scales has high viability against BHK21 fibroblast cells.
Highlights
Periodontal disease is a chronic bacterial infection characterized by persistent chronic inflammation, connective tissue damage, and bone destruction [1]
Collagen extracted from gouramy fish scales had no influence statistically on cultured fibroblast cells with a statistical significance (2-tailed) value of 0.754 (p>00025)
Collagen extracted from gouramy fish scales has high viability against baby hamster kidney fibroblasts-21 (BHK21) fibroblast cells
Summary
Periodontal disease is a chronic bacterial infection characterized by persistent chronic inflammation, connective tissue damage, and bone destruction [1]. The bone damage that accompanies periodontal disease varies greatly. The same patient in different areas can have different damage types. Periodontal treatments needed to deal with the tissue destruction vary [2]. The periodontal treatments have changed over three decades from resective to regenerative. The regenerative technique requires bone grafts, bioactive molecules, and membranes [3]
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