Abstract
A new pulse sequence, CHORUS Oneshot, allows measurements of diffusion-ordered spectroscopy (DOSY) spectra over the full chemical shift range of (19)F for the first time. Swept-frequency pulses are used to give very broadband excitation; the sequence is a prototype for a large family of very broadband liquid state NMR methods.
Highlights
Swept-frequency pulses are used to give very broadband excitation; the sequence is a prototype for a large family of very broadband liquid state NMR methods
Most diffusion-ordered spectroscopy (DOSY) spectra to date have been of 1H, but the method is most powerful for nuclei with wide chemical shift ranges such as 19F, for which signal overlap is rare. 19F DOSY is of particular interest because of the increasing use of fluorine in pharmaceuticals: a quarter of drugs currently on the market contain fluorine.[5]
Off-resonance effects mean that only a small fraction of the 19F chemical shift range can be excited at any one time using existing DOSY experiments; even experiments on narrow chemical shift ranges show significant anomalies.[6]
Summary
A new pulse sequence, CHORUS Oneshot, allows measurements of diffusion-ordered spectroscopy (DOSY) spectra over the full chemical shift range of 19F for the first time. DOSY is a powerful analytical tool, dispersing the NMR signals of a mixture according to the diffusion coefficients of the individual species involved.[1,2,3,4] Most DOSY spectra to date have been of 1H, but the method is most powerful for nuclei with wide chemical shift ranges such as 19F, for which signal overlap is rare.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call