Abstract
Verruciform xanthoma is an uncommon benign lesion of unknown etiology that mainly affects the oral mucosa. Clinically, this painless plaque has a papillary or verrucous surface. Man, 52, was referred for evaluation of an asymptomatic lesion on the palate. The lesion had appeared 6 years earlier, but had never been treated. Intraoral examination showed a 0.8-cm, well-demarcated, rounded whitish plaque with a verrucous surface and reddish background on the left side of the hard palate. The patient denied prior local trauma and reported tobacco use. Papilloma was the presumptive clinical diagnosis and an excisional biopsy was performed. Histopathological analysis revealed papillary epithelial hyperplasia and foamy macrophages in the lamina propria papillary zone. After 1 month of follow-up there is no sign of recurrence. The histopathological characterization of verruciform xanthoma is essential for the diagnosis, which clinically is often mistaken for a papilloma, condyloma, or wart.
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