Abstract
Verruciform xanthoma (VX) is an uncommon mucocutaneous benign, slow-growing lesion, most commonly affecting the masticatory mucosa of adults. We report 3 well-documented new cases of oral VX affecting men (mean age 47 years; range 29-72 years). Lesions clinically appeared as asymptomatic plaques measuring less than 2 cm with rough or papillary surface and yellowish to orangish coloration, affecting the hard palate (2 cases) and lower posterior alveolar ridge (1 case). VX was considered as a provisional diagnosis in one case. Microscopic analyses showed papillary hyperkeratotic epithelium with eosinophilic parakeratin plugs covering subepithelial connective tissue containing foamy macrophages. All patients are currently stable, with no signs of recurrence after follow-up of 6 to 18 months. Although uncommon in the oral cavity, clinicians should consider VX when evaluating oral papillary lesions, particularly on the masticatory mucosa.
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