Abstract
The aim of this study was to compare macular thickness measurements obtained from time-domain optical coherence tomography (OCT) and spectral-domain OCT to evaluate their agreement. Fifty randomly assigned subjects were included. Twenty-five were male, twenty-five female. In all cases both eyes were measured. Serial measurements were obtained from time-domain (StratusOCT, Zeiss) and spectral-domain OCT (Heidelberg Engineering, Germany). Total and regional macular thicknesses were obtained from both machines. Their agreement was estimated by Bland Altman plots. The foveal and total macular thicknesses measured by 3D OCT were significantly greater than those measured by StratusOCT (p < 0.001). While both time-domain and spectral-domain OCTs are reliable for macular thickness measurements, spectral-domain OCT delivers significantly higher values for macular thickness compared to the time-domain OCT. Macular measurements obtained from the two OCT systems may not be used interchangeably.
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