Abstract
Verbascum thapsus is naturally grown in the Himalayas and widely used in herbal teas and traditional herbal medicine for its anticarcinogenic and anti-inflammatory properties. The present study was designed to majority of leaf extracts from Verbascum thapsus. All extracts were analysed for phytochemical properties, antioxidant capacity and antimicrobial potential against both Gram-positive and Gram-negative bacteria. Biochemical investigations and GC-MS analysis was used for identifying phytochemicals. DPPH assay, Kirby’s Disc Diffusion method (KDM), 96 well test, and Resazurin test were performed for antioxidant and antimicrobial investigation. Results indicate that verbascum thapsus grown in Pakistan is rich in alkaloids and phenols. Noteworthy antibacterial activity was observed against S. sonnei, L. lactis, B. subtilis, C. freundii, K. oxytoca, L. monocytogenes, and S. enterica. GCMS analyses of V. thapsus extracts revealed the presence of medically important bio compounds including Hexadecanoic acid, methyl es and Stigmasterol (antibacterial activity), 2(5H)-Furanone (appetite suppressant), 3-Hydroxy-.beta.-damascone (anti-inflammatory properties), Squalene (antiaging, anti-inflammatory, anti-acne, eczema), Vitamin E and 2-Methoxy-4-vinylphenol (antioxidants). Antioxidant radical scavenging activity was determined from acetone extract of V. thapsus. This study concludes remarkable antibacterial and antioxidant potential in Verbascum Thapsus leaf extracts
Highlights
Cure of microbial ailments via plant extracts is in practice for centuries[1] deals with infectious diseases because of their antibiotic and antioxidant potential
The phytochemical profiling of Verbascum thapsus extracts in methanol, ethanol, water, acetone, and hexane was performed to reveal phenol, alkaloids, tannins, saponins, cardiac glycosides, flavonoids, water-soluble phenols, water-insoluble phenols, triterpenoids, free anthraquinones, and combined anthraquinones (Table 1)
The present study explored the promising antibacterial activity of V. thapsus against L. lactis, E. coli, and K. oxytoca
Summary
Cure of microbial ailments via plant extracts is in practice for centuries[1] deals with infectious diseases because of their antibiotic and antioxidant potential. Verbascum thapsus known as common mullein is utilized as traditional medicine and tea rich in antioxidants and antibacterial plants for long time[1,2]. Thapsus have expectorant and anti-inflammatory potential in herbal medicines[4]. Prominent medicinal uses include treatment for Parkinson’s disease, diabetes, bronchitis, asthma, joints and stomach pain, and skin issues etc[3]. In continuation of prior studies, the present study aims to explore multiple aspects i.e., phytochemical analyses of Verbascum thapsus and quantitative/qualitative investigations via GCMS and its antibacterial activities in five different solvents (Figure 1)
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