VERAPAMIL, NIFEDIPIN VƏ DILTIAZEMIN QANIN PLAZMASINDA ESTRADIOLUN QATILIĞINA TƏSIRININ TƏDQIQI

Abstract

The effect of long-term intake of calcium antagonists on the concentration of estradiol in the blood was studied. The studies were carried out on 82 female white rats, grown in laboratory conditions, weighing 180-230 grams, which have reached puberty at the Scientific Research Center of the Azerbaijan Medical University. Verapamil 5, 25 mg/kg (Isoptin, Abbot Laborato-ries S.A., Italy), nifedipine 5, 10 mg/kg (Farmadipin, Farmak Ukraine), diltiazem 5, 20 mg/kg (Diltizem-L, MNIS-Istanbul ) were used in the research. ) was used. The concentration of estra-diol in blood plasma was determined by enzyme immunoassay using the BioScreen MS-500 de-vice. Blood was taken from the hearts of experimental animals under ether anesthesia. To de-termine the concentration of the hormone estradiol in the blood, a set of reagents "Eliza Kit Es-tradiol" was used. Estradiol levels were 3.9% lower and 40.4% higher with verapamil (5 mg/kg) compared with control females in females receiving long-term treatment with nifedipine at a dose of 5 mg/kg. With long-term use of diltiazem at a dose of 5 mg/kg, the concentration of es-tradiol differed by 3.3% (p>0.05). With a corresponding increase in doses, nifedipine 10 mg/kg (65.0±2.4) > diltiazem 20 mg/kg (39.3±0.7) > verapamil 25 mg/kg (34.3±0.7) increased the con-centration estradiol.