Abstract
Verapamil, a calcium channel antagonist, causes a reduction of intraocular pressure in humans. This study investigated whether verapamil's effect on intraocular pressure was related to increased outflow facility. Six pairs of human eyes were dissected and anterior segments were perfused under constant pressure with concentrations of verapamil HCl ranging from 10(-10)-10(-3) M. The maximal increase of outflow facility over baseline was 64% at 10(-9) M. These results indicate that verapamil causes a dose related increase in outflow facility in human eyes, which may account for the reduced intraocular pressure following topical administration of verapamil.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.