Abstract
Among the four treatment regimens studied, the polymer-coated pancrealipase appears to be the preferred treatment for pancreatic enzyme replacement in cystic fibrosis. None of the pancreatic enzyme supplements used, however, alone or with the addition of bile salts, antacid, or enteric coating, completely corrected the malabsorption of fat. The effect of higher doses of the polymer-coated pancrealipase or the addition of antacids or cimetidine therefore need to be examined for the possibility of further clinical improvement. Alternatively, mucosal absorption of fatty acids may be impaired and further improvement of pancreatic enzyme replacement may not completely abolish steatorrhea. TM The authors are grateful to the nurses and nutritionists of the Clinical Research Center and to Mrs. Linda Timmons for her secretarial help. REFERENCES 1. Graham DY: Enzyme replacement therapy of exocrine pancreatic insufficiency in man, N Engl J Med 296:1314, 1977. 2. DiMagno EP, Malagelada JR, Go VLW, and Moertel CG:
Published Version
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