Abstract
Two clinical Pseudomonas aeruginosa isolates from patients in intensive care units in Kuwait were resistant to expanded-spectrum cephalosporins and showed a synergistic effect between ceftazidime and clavulanic acid. This is the first report of extended-spectrum enzymes from nosocomial isolates from the Middle East.
Highlights
Pseudomonas aeruginosa has an inducible, naturally occurring cephalosporinase that confers low-level resistance to aminopenicillins and narrow-spectrum cephalosporins such as cephalothin and cefoxitin [1]
We report on two novel VEB-1-like beta-lactamases from P. aeruginosa clinical isolates from Kuwait
Preliminary polymerase chain reaction (PCR) experiments were performed with DNAs of P. aeruginosa KU-1 and KU-2 as templates and primers specific for the following class A beta-lactamases: TEM, SHV, CARB (PSE-1), GES-1, PER-1, and VEB-1 [3,5,9,10,11]
Summary
Pseudomonas aeruginosa has an inducible, naturally occurring cephalosporinase that confers low-level resistance to aminopenicillins and narrow-spectrum cephalosporins such as cephalothin and cefoxitin [1]. Another class A ESBL integron-located gene, blaVEB-1, has been identified from P. aeruginosa and enterobacterial isolates from Southeast Asia [5,6,7]. We report on two novel VEB-1-like beta-lactamases from P. aeruginosa clinical isolates from Kuwait.
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