Abstract
Background: Cognitive changes are often reported in Parkinson’s disease (PD). Numerous studies showed that there are changes in the patterns of inflammation when vascular dementia progressed, but the role of inflammation in PD is unknown. Methods: 75 consecutive diagnosed PD patients included. Patients divided into idiopathic PD (n=55) and PDD (n=20) based on DSM–IV criteria for diagnosis of dementia. Serum levels of vascular and inflammatory biomarkers for interleukin-6 (IL-6), high sensitivity-C reactive protein (hs- CRP), soluble intracellular cell adhesion molecule (ICAM-1), soluble vascular cell adhesion molecule (VCAM-1) investigated by ELISA assay and compared between PD and PDD. Result: The significant enhancement of the VCAM-1 only found in serum of PDD compared to PD (56/06 ± 58/16 ng/ml vs. 30/43 ± 38/30, P=0/04), even after adjustment age, gender and hypertension (OR=1/01, P=0/05). Cut-off point of VCAM-1 levels was equal to or greater than as 40/14 ng/ml for differentiating dementia in PD from PD without dementia with sensitivity and specificity were 73%, 64%. Conclusion: PDD patients had significant higher levels of VCAM-1 than PD, suggesting the serum levels of VCAM-1 may be a useful marker for PDD diagnosis. Future studies are needed to investigate possible association betweenVCAM-1 levels in PDD in larger sample size.
Highlights
Dementia in neurodegenerative disorders such as Parkinson’s disease (PD) was as an impairment in the structure and function of cerebral blood vessels and associated cells, and these effects are mediated by inflammation [1]
Our results proposed VCAM-1 as a modifiable vascular risk factor for PDD
For comparison between mechanisms of dementia in Alzheimer's disease and Vascular dementia, Engelhart et al showed no changes in the plasma levels of VCAM-1 and ICAM-1 in Dementia, AD and VD [5], Hochstrasser did not reveal that VCAM- affected in monocytes of AD and MCI patients [17,18]
Summary
Dementia in neurodegenerative disorders such as Parkinson’s disease (PD) was as an impairment in the structure and function of cerebral blood vessels and associated cells (neurovascular unit), and these effects are mediated by inflammation [1]. Some studies showed that plasma levels of inflammatory markers such as Interleukin-6 (IL-6) and high sensitivity Creative protein (hs-CRP) increased in the early stages of PD and in the early stages of Cognitive decline leading to AD [6]. The Present study designed to answer the question whether the inflammatory biomarkers have a suitable power in comparing to vascular biomarkers for diagnosis of dementia in PD, so, we investigate the serum concentration of hs-CRP and IL-6 as representative of systemic inflammation and ICAM-1 and VCAM-1 as vascular biomarkers. Serum levels of vascular and inflammatory biomarkers for interleukin-6 (IL-6), high sensitivity-C reactive protein (hsCRP), soluble intracellular cell adhesion molecule (ICAM-1), soluble vascular cell adhesion molecule (VCAM-1) investigated by ELISA assay and compared between PD and PDD.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
