Vaspin Attenuates High Glucose-Induced Inflammation and Apoptosis in Human Retinal Pigment Epithelium Cell

Abstract

Diabetic retinopathy (DR) is identified as a serious microvascular complication of diabetes mellitus (DM). Vaspin (visceral adipose tissue-derived serine protease inhibitor) is known as a novel adipokine that associated with pathological process of DM. The present study aims to investigate the underlying mechanism related to the role of vaspin in the pathogenesis if DR. In present study, vaspin treatment attenuated high glucose-induced cell injury and inflammation in ARPE-19 cells. In addition, vaspin suppressed oxidative stress status and cell apoptosis in ARPE-19 cells with high glucose challenge. Furthermore, inactivation of Nod-like receptor P3 (NLRP3) inflammasome pathway may be associated with the anti-inflammation, antioxidant and anti-apoptosis activities of vaspin. Together our findings suggest that vaspin protected against inflammation and cell apoptosis in the pathological process of DR. Hence, vaspin may represent as an effective agent for clinical therapy of DR.