Abstract
As is well known, autophagy activation is associated with the progression of oral squamous cell carcinoma (OSCC) cells, and regulating the development of autophagy is beneficial for improving cancer treatment. ATG5 plays an irreplaceable role in autophagy and many important processes of cell, can be used as a therapeutic target for tumors. We use G0-C14 cationophore, which efficiently carries siATG5 to form stable nanoparticles (siA/NPs). SiA/NPs successfully escapes lysosomes, releases siATG5 and efficiently silences ATG5, has a certain OSCC lethality. This provides a direction for the targeted autophagy treatment of future OSCC therapy.
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