Abstract
Exercise training protects against age- and lifestyle-related diseases. We recently reported that middle-aged and older Japanese men carrying the TT genotype of the single nucleotide rs1042615 polymorphism in the vasopressin V1a receptor had significantly higher body mass index and diastolic blood pressure than those who did not. However, these higher values decreased to levels comparable to those of men carrying other genotypes following 5 months of interval walking training (IWT), suggesting that they might have been physically inactive before starting IWT. Therefore, we postulated that TT men would have lower adherence to long-term exercise programs. To assess this, middle-aged and older men underwent IWT for 29 months. We found that adherence to the exercise program was markedly decreased in TT men compared with men of other genotypes during the training period.
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