Abstract
Results of this study show that 18 of 20 dogs survived prolonged periods of arterial hypotension when phenoxybenzamine was given to maintain adequate flow to the vital tissues of the body. This drug was used in order to block the catecholamine-induced arteriolar vasoconstriction and the histamine-induced venospasm. Reduction of peripheral resistance results in an increased perfusion of the capillary beds and a correction of O2 and CO2 tensions at the tissue level. One must emphasize the need for adequate fluid replacement, with this form of therapy; otherwise the marked vasodilation which occurs with phenoxybenzamine might result in an inadequate circulation, even as the resistance to flow in hypoxic tissues is eliminated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
