Abstract
Sepsis develops in about 750,000 people annually and accounts for more than 210,000 deaths per year in the United States [1]. Pediatric severe sepsis is also a burdensome public health problem, with prevalence, morbidity, and mortality rates similar to reports from critically ill adult populations [2]. In sepsis inflammatory mediators lead to circulatory abnormalities including peripheral vasodilatation, reduced mean arterial pressure (MAP), myocardial depression, and intravascular volume depletion [3]. With increased awareness and the use of protocolized care in the emergency department and in the intensive care unit (ICU) the mortality associated with sepsis has decreased significantly in the last decade in some countries [4,5].
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