Abstract
BackgroundSurvival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis. Vasculogenic mimicry (VM) is an alternative type of blood supplement related to more aggressive tumor biology and increased tumor-related mortality. This study aimed to investigate the unique role of VM in the progression of LSCC.MethodsWe reviewed clinical pathological data of 203 cases of LSCC both prospectively and retrospectively. VM and endothelium-dependent vessel (EDV) were detected by immunohistochemistry and double staining to compare their different clinical pathological significance in LSCC. Survival analyses were performed to assess their prognostic significance as well.ResultsBoth VM and EDV existed in LSCC type of blood supply. VM is related to pTNM stage, lymph node metastasis and pathology grade. In contrust, EDV related to location, pTNM stage, T stage and distant metastasis. Univariate analysis showed VM, pTNM stage, T classification, nodal status, histopathological grade, tumor size, and radiotherapy to be related to overall survival (OS). While, VM, location, tumor size and radiotherapy were found to relate to disease free survival (DFS). Multivariate analysis indicated that VM, but not EDV, was an adverse predictor for both OS and DFS.ConclusionsVM existed in LSCC. It contributed to the progression of LSCC by promoting lymph node metastasis. It is an independent predictors of a poor prognosis of LSCC.
Highlights
Survival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis
Evidence of Vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) in LSCC Both VM and EDV existed in LSCC
We identified that the positive rate of VM in LSCC is 21.67%, which is different from other tumors, such as inflammatory and ductal breast carcinoma (7.9%), ovarian carcinoma(36.4%), melanoma(5.3%), rhabdomyosarcoma(18.8%), and synovial sarcoma(13.6%)
Summary
Survival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis. This study aimed to investigate the unique role of VM in the progression of LSCC. Laryngeal squamous call carcinoma (LSCC) is the second main upper respiratory tract tumor behind lung cancer in incidence and mortality rates. Despite many advances in the diagnosis and treatment of the disease, its overall survival rate has remained unchanged (at approximately 3570%) over the past several decades. It is mainly due to uncontrolled recurrence and local lymph node metastasis[1]. It is necessary to develope new therapeutic targets for LSCC that can take advantage of the unique qualities of this disease. It is traditionally known that tumor invasion and metastasis mainly depend on angiogenesis. The results of studies associating microvessel density and various clinical pathological parameters and/
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