Abstract
Recent evidence indicates that the type II transforming growth factor- β (TGF- β) receptor (T βRII) is a serine-threonine-tyrosine kinase. However, the significance of its tyrosine kinase is unclear. We investigated in vascular smooth muscle cells the effects of tyrosine kinase inhibition on the expression of TGF- β receptor types I (ALK-5) and II (T βRII) mRNA, induced by TGF- β 1. TGF- β 1 elevated ALK-5 mRNA levels 5-fold; essentially similar TGF- β 1-dependent elevations were observed with growth factors, PDGF-BB and FGF-2. The tyrosine kinase inhibitor genistein abolished these TGF- β 1 and growth factor responses. TGF- β 1 also elevated T βRII mRNA levels which were not inhibited by genistein. We conclude that tyrosine kinases participate in defining how cells respond to TGF- β.
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