Abstract
Fourteen cases with intracranial vascular tumors including 5 hemangioblastomas, 7 hemangiopericytic meningiomas, and 2 hemangioblastic meningiomas were investigated by immunohistochemistry using antibodies against alpha-smooth muscle actin, alpha tubulin, collagen type 4, desmin, epithelial membrane antigen (EMA), fibronectin, cytokeratin AE1/AE3, myosin and vimentin. A positive immunoreactivity for EMA was observed in the tumor cells of hemangioblastic meningiomas. Since other vascular tumors did not react with EMA antibody, EMA immunostaining seemed to be useful for differencing hemangioblastic meningioma from other types of vascular neoplasms. Alpha-smooth muscle actin proved to be an excellent marker of vascular pericytes. Tumor cells of hemangiopericytic meningiomas, however, did not immunostain with alpha-smooth muscle actin antibody. This does not support the theory of a pericytic origin for hemangiopericytic meningioma. Neither an endothelial marker nor a pericytic marker was detected in stromal cells of the hemangioblastomas. The histogenesis of the stromal cells remains to be ascertained.
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