VASCULAR REFLEX RESPONSES INDUCED BY AN INTRAARTERIAL INJECTION OF AZAAZEPINOPHENOTHIAZINE, ANDROMEDOTOXIN, VERATRIDINE, BRADYKININ AND KALLIKREIN AND BLOCKING ACTION OF SODIUM SALICYLATE.

Abstract

The cross circulation technique was applied for perfusing the innervated hindlimb and kidney preparation for analysing the reflex response in the systemic blood pressure and the respiratory movement, when dimethylaminopropyl-tetrahydro-azaazepino-phenothiazine (RPP 201), andromedotoxin, veratridine, bradykinin and kallikrein were injected into the femoral artery of hindlimb preparation.The pressor reflex response was constantly observed by use of RPP 201, andromedotoxin and veratridine but the depressor, or the pressor or the combined reflex was obtained by use of bradykinin and kallikrein. The depressor reflex induced by bradykinin disappeared when the skin of leg was removed, while the pressor reflex was reversed to the depressor one by preceding injection of sodium salicylate into the femoral artery. The pressor reflex with respiratory excitation induced by RPP 201 was also blocked by sodium. salicylate. The afferent fibers in the sciatic nerve were principally responsible to the reflex, and anticholinergic, antiadrenergic, antihistamic, antiserotonic, neuromusclar blocking and ganglion blocking agents did not block the reflex but procaine did it. Authors conclude that the depressor reflex response is probably induced by the excitation of afferent fiber from the skin while the pressor one is originated from the muscle, joint and other parts than the skin, and that sodium salicylate blocks peripherally these nociceptive or pseudoaffective reflex responses, especially originated from the muscle and joint but not from the skin.