Vascular endothelial growth factor during physical loads with different mechanism of energy's providing of muscular work

Abstract

In the article the results of investigation of vascular endothelial growth factor's (VEGF) maintenance changes at the oxidative stress caused by physical activities and associated tissue hypoxia, for the representatives of types of sport with the different mechanisms of energy providing of muscular work are presented. The highest VEGF concentration of serum was marked in sports with representatives of aerobic energy supply mechanism of muscle activity--from 122.8±3.4 to 126.2±4.1 pg·ml(-1), intermediate values in VEGF marked in a mixed mechanism energy--102.4±4.91 pg·ml(-1). Anaerobic muscle activity observed providing the lowest of VEGF value (78.5±5.2 pg·ml(-1)). Initial VEGF concentration in athletes even before the current load is higher than in the healthy untrained people. A statistically significant positive correlation between the degree of antioxidant protection and the VEGF concentration has been found. It is concluded, that angiogenesis is one of the mechanisms of adaptation to tissue hypoxia during physical activities. Scientific Institute of the National University of Physical Education and Sport of Ukraine, Kiev.