Abstract
Methods Six age groups were defined: 3-4 d (Group A), 5-7 d (Group B), 8-10 d (Group C), 11-15 d (Group D), 16-20 d (Group E), and 21-28 d (Group F). Amino acid, free carnitine, and acylcarnitine concentrations of dried whole blood spots were obtained from the MS/MS analysis. Linear regression analyses of all results of highly diseaserelated analytes were carried out to identify covariates associated with sampling time in Matlab. For the respective regression coefficients (RC), plus represents the analyte levels elevate as the sampling time prolongs, and vice versa for minus.
Highlights
Variations of amino acid, free carnitine and acylarnitine profiles analysed by tandem mass spectrometry in newborns during their first four weeks of life
International Journal of Pediatric Endocrinology 2015 2015(Suppl 1):P120
Summary
Variations of amino acid, free carnitine and acylarnitine profiles analysed by tandem mass spectrometry in newborns during their first four weeks of life. From 8th APPES Biennial Scientific Meeting Darwin, Australia. Aims Electrospray ionization-tandem mass spectrometry (MS/ MS) has increasingly been advocated for expanded newborn screening and for the early diagnosis of amino acidemias, fatty acid oxidation disorders, and organic acidurias. We characterized amino acid, free carnitine, and acylcarnitine status with respect to postnatal ages in 158,730 newborns over the last two years
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