Abstract
BackgroundGonadotropin releasing hormone agonists (GnRHa) are well established as a standard of care for the treatment of central precocious puberty (CPP) worldwide. While numerous delivery systems and routes of administration exist, depot intramuscular injections or sustained-release preparations have been most widely used. Leuprolide acetate is well tolerated among children though some can develop some complications.Case presentationWe present a case report of a 6.5 year old girl with central precocious puberty who developed signs of pseudotumor cerebri after 2 doses of leuprolide acetate 3.75 mg given monthly. Systemic exam and other tests to look for the cause did not yield anything. However, fundoscopy showed marked papilloedema with blurred disc margins. After six weeks’ treatment with acetazolamide and withdrawal of the GRNHa the papilloedema resolved.ConclusionsIf a patient presents with complaints such as headache, nausea, vomiting, and double vision in pediatric patients treated with GnRH analogue one should highly consider the presence of pseudotumor cerebri and fundus examination be performed.
Highlights
Gonadotropin releasing hormone agonists (GnRHa) are well established as a standard of care for the treatment of central precocious puberty (CPP) worldwide
We present a case report of a girl with central precocious puberty who developed pseudotumor cerebri with visual loss associated with the use of leuprolide acetate a Gonadotropin Releasing Hormone (GnRH) analogue
Central precocious puberty (CPP) is amenable to management with GnRH analogues that operate on physiological principles by desensitizing the signaling pathway to gonadotrophin production [6]
Summary
Gonadotropin releasing hormone agonists (GnRHa) are well established as a standard of care for the treatment of central precocious puberty (CPP) worldwide. Histrelin acetate implant which is approved for 12 months treatment, has been found to be effective for upto 2 years [1, 2]. * Correspondence: anjumomar@yahoo.com 1Department of Paediatrics and Child Health-Nairobi, University of Nairobi, Nairobi, Kenya Full list of author information is available at the end of the article monthly depot GnRHa were most frequently used.
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