Abstract
The expression of a selected suite of 192 metabolic genes in brain, heart and liver in three populations of the teleost fish Fundulus heteroclitus was examined. Only a small subset (31%) of tissue-specific differences was consistent in all three populations, indicating that many tissue-specific differences in gene expression are unique to one population and thus are unlikely to contribute to fundamental differences between tissue types.
Highlights
Variation in gene expression is extensive among tissues, individuals, strains, populations and species
Genes involved in oxidative phosphorylation are highlighted in green, and expression patterns that are consistent across all three populations are highlighted with a blue triangle
We suggest that patterns of expression that are consistent in different populations are more likely to be functionally important
Summary
Variation in gene expression is extensive among tissues, individuals, strains, populations and species The interactions among these sources of variation are relevant for physiological studies such as disease or toxic stress; for example, it is common for pathologies such as cancer, heart failure and metabolic disease to be associated with changes in tissue-specific gene expression or changes in metabolic gene expression. How conserved these differences are among outbred individuals and among populations has not been well documented. These genes are differentially expressed among individuals within treatments
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