Abstract
ABSTRACT Objectives Krüppel‑like factors (KLFs) are implicated in the progression of endometrial cancer (EC). This present study explored the correlation between variants of KLF5, KLF12 and EC risk in the Chinese population. Methods The Agena MassARRAY technology platform was utilized to genotype six single nucleotide polymorphisms (SNPs) in KLF5 and KLF12 genes among 509 women diagnosed with EC and 506 age-matched healthy women. Subsequently, the relationship between SNPs in KLF5 and KLF12 and EC risk was calculated using logistic regression analysis. The interactions between SNPs in KLF5 and KLF12 were analyzed to predict EC risk using multifactor dimensionality reduction (MDR) analysis. Results KLF12 rs12429889 was significantly associated with EC risk (codominant: OR = 1.53, p = 0.003; dominant: OR = 1.54, p = 0.004). In addition, rs7329599 was significantly associated with EC risk in participants aged ≤55 years (codominant: OR = 0.63, p = 0.014; dominant: OR = 0.67, p = 0.024), whereas rs12429889 was significantly associated with EC risk in participants aged >55 years (codominant: OR = 1.98, p = 0.004; dominant: OR = 2.06, p = 0.002). Conclusion Our findings revealed a significant correlation between KLF12 rs12429889 and rs7329599 and EC risk, highlighting their potential as diagnostic biomarkers.
Published Version
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