Abstract
The article discusses key issues on the relationship between the qualitative and quantitative characteristics of mtDNA and the risks of atherosclerosis and myocardial infarction. Russian and international research literature was analyzed regarding point and deletion mutations in mtDNA, including heteroplasmy, related to the risks of developing cardiovascular diseases and acute cardiovascular events. The review also discusses the relationship between cardiovascular events and oxidative stress severity, the number of intracellular and free-circulating mtDNA copies.
Highlights
Митохондрии кардиомиоцитов обеспечивают функцию клеточного дыхания; структурная и количественная составляющие Митохондриальная ДНК (мтДНК) напрямую связаны с рисками развития острых сосудистых катастроф
Environmental factors may influence the functional potential and structure of mtDNA, which is accompanied by impaired cellular respiration and leads to the development of cardiovascular diseases
The onset of myocardial infarction is directly related to ischemic-reperfusion injury of myocardial cells and oxidative stress
Summary
Возникновение инфаркта миокарда напрямую связано с ишемически-реперфузионнным повреждением клеток миокарда и оксидативным стрессом. Митохондрии кардиомиоцитов обеспечивают функцию клеточного дыхания; структурная и количественная составляющие мтДНК напрямую связаны с рисками развития острых сосудистых катастроф. Средовые факторы оказывают влияние на функциональный потенциал и структуру мтДНК, что сопровождается нарушениями клеточного дыхания и приводит к развитию заболеваний сердечно-сосудистой системы
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