Abstract
Twelve anesthetized dogs, underwent hypothermic cardiopulmonary bypass. 6 digs received vardenafil (30 μg/kg) prior initiation of cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started. Left ventricular end-systolic pressure volume relationship (Ees) was measured by a combined pressure-volume-conductance catheter at baseline and after 60 minutes of reperfusion. Left anterior descendent coronary blood flow (CBF) and endothelium-dependent vasodilatation to acetylcholine (ACH) were determined.
Highlights
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
In the present pre-clinical study, we investigated the effects of vardenafil pretreatment on myocardial and endothelial function in an experimental model of cardioplegic arrest and extracorporal circulation
Application of vardenafil improves myocardial and endothelial function after cardiopulmonary bypass with hypothermic cardiac arrest
Summary
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. . Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass Gábor Szabó*1,2, Gábor Veres1,2, Tamás Radovits1,2, Christiane Miesel-
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