Year-end Sale % OFF 
Abstract
Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures, protein–protein interactions, phenotypes and so forth. The knowledge accumulated by all the omics research is so vast that a computer-aided search of data is now a prerequisite for starting a new study. In addition, a combinatory search throughout these databases has a chance to extract new ideas and new hypotheses that can be examined by wet-lab experiments. By virtually integrating the related databases on the Internet, we have built a new web application that facilitates life science researchers for retrieving experts’ knowledge stored in the databases and for building a new hypothesis of the research target. This web application, named VaProS, puts stress on the interconnection between the functional information of genome sequences and protein 3D structures, such as structural effect of the gene mutation. In this manuscript, we present the notion of VaProS, the databases and tools that can be accessed without any knowledge of database locations and data formats, and the power of search exemplified in quest of the molecular mechanisms of lysosomal storage disease. VaProS can be freely accessed at http://p4d-info.nig.ac.jp/vapros/.
Highlights
The advance of the molecular biology has yielded a huge amount of biological data including DNA/RNA/protein sequences [1,2,3], their expression levels [4], difference in the sequences of individuals [5], three-dimensional (3D) structures of the biomolecules [6], phenotypes of the organisms [7] and so forth
We present the notion of VaProS, the databases and tools that can be accessed without any knowledge of database locations and data formats, and the power of search exemplified in quest of the molecular mechanisms of lysosomal storage disease
These data have been stored in independent databases located on the Internet and researchers exploit these databases for new knowledge of the target of their study
Summary
The advance of the molecular biology has yielded a huge amount of biological data including DNA/RNA/protein sequences [1,2,3], their expression levels [4], difference in the sequences of individuals [5], three-dimensional (3D) structures of the biomolecules [6], phenotypes of the organisms [7] and so forth These data have been stored in independent databases located on the Internet and researchers exploit these databases for new knowledge of the target of their study. Some efforts have been dedicated to solve these difficulties (e.g., http://identifiers.org), it will take time for the research community to agree on a unified convention To overcome these difficulties in a search of multiple databases in the information of life science, we started developing a new type of application that searches databases in different locations simultaneously by a simple search query and displays the result in a simple interface at http://p4d-info.nig.ac.jp/vapros/. The detail of VaProS and the example of the usage are presented
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
