Abstract
Reaction of VOCl 2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products [VO(H2Am4DH)Cl 2] ( 1), [VO(H2Am4Me)Cl 2] · 1/2HCl ( 2), [VO(H2Am4Et)Cl 2] · HCl ( 3) and [VO(2Am4Ph)Cl] ( 4). Upon the dissolution of 1– 4 in water, oxidation immediately occurs with the formation of [VO 2(2Am4DH)] ( 5), [VO 2(2Am4Me)] ( 6), [VO 2(2Am4Et)] ( 7) and [VO 2(2Am4Ph)] ( 8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5– 8 inhibited glycerol release in a similar way to that observed with insulin but showed a low enhancing effect on glucose uptake by rat adipocytes.
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