Abstract
Microfluidic devices can produce highly monodisperse drops at kilohertz rates using flow-focus drop formation. We use single-layer membrane valves to control, in real time, the dimensions of the flow-focus drop makers. This allows drop size and frequency to be controlled in real time and without adjusting flow rates.
Highlights
Picoliter drops made in microfluidic devices can serve as individual compartments for chemical reactions1 and can be processed at kilohertz rates with high precision
Continuous-flow microfluidics can operate at very high throughput
As with drop-on-demand devices, continuous-flow microfluidics can be structured like an assembly line, enabling complex tasks to be efficiently performed
Summary
Throughput of continuous-flow microfluidics, with the timing and control of drop-on-demand devices. We use membrane valves to control the dimensions of the flow-focus side channels, thereby enabling drop frequency to be controlled.
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