Value of N-terminal pro-brain natriuretic peptide in predicting coronary heart disease

Abstract

Objective To analyze the relationship between N-terminal pro-brain natriuretic peptide(NT-proBNP) and coronary heart disease(CHD) and to determine whether it could be used as a predictor of CHD. Methods One hundred and eleven patients hospitalized were recruited from January 2012 to September 2014, 89 patients with CHD diagnosed by coronary angiography as the research objects, and 22 patients without CHD diagnosed by coronary angiography as control. The severity of angiographic lesions was assessed with the Gensini scoring system. Among 89 CHD patients, 56 cases with acute coronary syndrome(ACS group) and 33 cases with stable angina pectoris(SAP group); 35 patients with single branch lesion, 21 patients with double branchs lesion, 33 patients with multivessel lesion. The association between NT-proBNP and CHD was obtained with multiple statistical methods. Results Plasma NT-proBNP concentration in patients from high to low were the ACS group>SAP group>control group; Multivessel lesions group>double vessels lesions>single vessel lesion group>the control group.The NT-proBNP concentration differences were statistically significant(P<0.05) between the ACS group and control group, multivessel lesions group and the control group, multivessel lesions and single vessel lesion group, the double vessels lesions group and control group. There was significant positive correlation between plasma NT-proBNP concentration and Gensini score. Conclusions Higher level of NT-proBNP in CHD patients underscores the potential role of NT-proBNP in predicting acute coronary events and the severity of CAD before performing angiography. Key words: Natriuretic peptide; Brain; Coronary heart disease; Gensini score