Relationship between N-terminal pro brain natriuretic peptide and insulin sensitivity index in pa-tients with unstable angina pectoris

Abstract

Objective To study the correlation of N-terminal pro brain natriuretic peptide（ NT-proBNP）with insulin sensitivity index（ FBG,FINS,FINS/FBG,ISI）in UAP patients,and its clinical significance. Methods One hundred patients with UAP were enrolled as the observation group,30 patients with stable angina pectoris（ SAP）as SAP group,and 30 healthy people as the normal control （COM）group. According to the Braunwald UAP,patients in UAP group were graded into 3 supgroups（ grade 1 ,grade 2 and grade 3 ）. The plasma NT-proBNP and insulin sensitivity indexes were detected in each group,and then the results were analyzed and the linear correlation analysis was made. Results The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with UAP and SAP group were significantly higher than those in COM group（ P﹤0. 05 ）,but ISI was lower than that in COM group（ P ﹤0. 05 ）. The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with UAP were significantly higher than those in patients with SAP（ P﹤0. 05 ）,but ISI was lower than that in patients with SAP（P﹤0. 05）,and there was no significant difference in FBG between the two groups. The concentration of plasma NT-proBNP,FINS,FINS/FBG in patients with grade 2 and grade 3 were significantly higher than those in patients with grade 1（ P﹤0. 05 ）,but ISI was lower in the grade 2（ P﹤0. 05）. No significant diference was found between grade 2 and grade 3. In UAP patients,the plasma NT-proBNP concentration was positively correlated with FINS,FINS/FBG（ r =0. 38,P =0. 046,r =0. 56 ,P=0. 039 ）,and negative correlated with ISI（ r = -0. 62 ,P =0. 028 ）,and with no correlation with FBG. Conclusions The concentration of plasma NT-proBNP was elevated and insulin sensitivity decreased in UAP, especially in Braunwald UAP grade 2 and grade 3（ rest angina ）,the concentration of NT-proBNP was negatively correlated with insulin sensitivity. The combined determination is significant in risk grading reference of UAP. Key words: Unstable angina pectoris; N-terminal pro brain natriuretic peptide; Insulin sensitivity index