Value of noninvasive DNA in screening for fetal aneuploidy in elderly pregnant women

Abstract

Objective To investigate the value of noninvasive DNA screening for fetal aneuploidy in elderly pregnant women, and to provide guidance for prenatal and postnatal care. Methods A total of 620 elderly pregnant women undergoing maternity examination in Yunfu Maternal and Child Health Hospital from January 2016 to June 2018 were selected as the subjects. They were randomly divided into direct group and indirect group, with 310 cases in each group. Direct amniotic fluid test was performed for pregnant women in direct group, and non-invasive DNA prenatal test was performed for pregnant women in indirect group, and the amniotic fluid test was performed in the positive patients. The detection rates of fetal chromosomal abnormalities between the two groups were compared and analyzed statistically. Results In indirect group, 310 pregnant women were tested for non invasive DNA, positive in 3 cases, and 3 cases had amniotic fluid detection, and the total chromosome abnormal detection rate was 0.97%. The direct amniotic fluid examination of 310 pregnant women in direct group revealed chromosomal abnormalities in 4 cases, and the detection rate of chromosomal abnormalities was 1.29%. There was no significant difference in the detection rate of chromosomal abnormalities between the two groups (P>0.05). Conclusions Non-invasive DNA prenatal detection technology can provide high accuracy prenatal diagnosis method for elder pregnant women and those who refuse amniocentesis. It has good clinical popularization value for prenatal and postnatal care. Key words: Non-invasive DNA; Prenatal examination; Elderly pregnant women; Amniotic fluid testing