Abstract
ABSTRACTObjectives:To investigate the positive detection rate and clinical application value of anti-parietal cell antibody (PCA), anti-neutrophil cytoplasmic antibody (ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), anti-gliadin antibody (AGA) and anti-nuclear antibody (ANA) in patients visiting the Department of Gastroenterology.Methods:From January 2015 to June 2018, 1,083 patients receiving detection of PCA and other autoantibodies were selected from the Department of Gastroenterology of Baoding First Central Hospital. The positive detection rate of autoantibodies was statistically analyzed. The enumeration data were expressed as rate or constituent ratio, and the rates were compared between groups using the x2 test.Results:Among the 1,083 patients, the positive detection rate of ANA, ASCA, AGA, PCA and ANCA was 33.52%, 16.71%, 15.51%, 13.66% and 7.66%, respectively. The total positive detection rate was 62.8% (n = 680).Conclusion:The population with abdominal distension, chronic abdominal pain, diarrhea and other digestive system symptoms should be timely treated with combined detection of PCA, ANCA, ASCA, AGA and ANA, which is of important clinical application value for early diagnosis of gastrointestinal diseases and prevention of missed diagnosis and misdiagnosis.
Highlights
Abdominal distension, chronic abdominal pain and diarrhea are common symptoms of patients visiting the Department of Gastroenterology, which are not specific and can be caused by multiple diseases
Pak J Med Sci January - February 2022 Vol 38 No 1 www.pjms.org.pk 227 the development of detection technologies and the development and application of various autoantibodies, the incidences of autoimmune gastrointestinal diseases such as inflammatory bowel disease (IBD), type A atrophic gastritis (AIG) and celiac disease have been increasing in recent years.[2,3,4]
Detection reagents for anti-nuclear antibody (ANA) and anti-neutrophil cytoplasmic antibody (ANCA) were from EUROIMMUN Medical Diagnostics Co., Ltd., and detection reagents for ACSA, anti-gliadin antibody (AGA) and parietal cell antibody (PCA) were from Guangzhou Kangrun Biotechnology Co., Ltd
Summary
Pak J Med Sci January - February 2022 Vol 38 No 1 www.pjms.org.pk 227 the development of detection technologies and the development and application of various autoantibodies, the incidences of autoimmune gastrointestinal diseases such as inflammatory bowel disease (IBD), type A atrophic gastritis (AIG) and celiac disease have been increasing in recent years.[2,3,4] Because of atypical early symptoms and similar clinical manifestations, their diagnosis mostly depends on endoscopy and pathology, and pathological development is a slow and gradual process, always resulting in diagnosis many years after the symptoms appear and very severe outcomes in many cases.
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