Abstract
Parchment is a coffee by-product with high amounts of polyphenols that could be effective in the prevention of obesity-related metabolic disorders. However, their effectiveness depends on their stability and bioavailability which could be improved by encapsulation. The aim of this study was to investigate anti-obesity effects of aqueous coffee parchment extract. Aqueous coffee parchment extracts were administrated orally (100 mg/kg weight/day) as free or in a microencapsulated form with whey protein/maltodextrin, in fructose-induced obesity rat model (20% fructose in water). Different metabolic parameters were determined. Parchment extract contained total phenolics at 79.50 mg GAE/g, with chlorogenic acid and caffeine as main compounds. The microencapsulation efficiency was 89.36% and SEM images revealed spherical microcapsules which exhibited polyphenol release under simulated digestion. Fructose obese rats displayed increased adiposity and metabolic alterations as hyperinsulinemia, hyperglycemia, hyperlipidemia and oxidative stress with high liver and adipose tissue lipids. The treatment with parchment extract prevented adipose fat accumulation and alleviated the hyperglycemia, hyperinsulinemia, hyperlipidemia, liver steatosis and oxidative stress in obese rats. The effects were more pronounced with encapsulation. Coffee parchment extract protected against fructose-induced obesity metabolic alterations; a better amelioration was observed with microcapsules which will increase the value of this coffee by-product.
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