Valoración de cuerpos amiláceos en epilepsia refractaria

Abstract

Objectives: The purpose of this study is to check whether there is or not a relationship between CoA density and different clinical parameters of the disease established. Compare the assessment of CoA with Hematoxylin-Eosin technique against PAS staining. It is also intended to check if it exists a relationship between hippocampal CoA density and Nestine overexpression. Methods: Histological analysis of 14 patients. For the counting of the CoA, raw scores were used interchangeably, as well as discretized values on a semi-quantitative scale according to Cherian et al. criteria. The modified Engel scale was used to measure post-surgical evolution. Results: The proportion of CoA in the hippocampus matches the proportion found in different studies: 64.3%. At α=0.05, there is significant evidence to observe that the counting is different depending on the type of staining used in the slides. The average number of CoA is higher with the PAS. It is seen that the density of CoA in the hippocampus and cortex is directly related to its density in parahypocampal structures. With regard to the relation between CoA density and age of onset, there are signs of significance. As well as in the post-surgical evolution. With regard to the duration of the crisis period, was found that both variables are independent. Finally, it is observed that there is a direct association between Nestine overexpression and hippocampal CoA density. Conclusion: In patients with Refractory Epilepsy (ER), CoA presence is commonly verified, with a better evaluation with PAS staining. Respectfully to the relation between CoA density and age of onset, there are signs of significance, as well as post-surgical evolution with the modified Engel scale. It would be convenient to continue with the investigations in this field to contrast the role of CoA in ER.