Abstract
Introduction Cardiac transplantation is a widely accepted option for the treatment of end-stage congestive heart failure. In order to identify those patients at risk of short life expectancy, it could be worthwhile to establish an individual prognosis factor. The prognostic and diagnostic values of natriuretic peptides have been studied in different areas of clinical practice. The objective of this study was to evaluate the short-term prognostic ability of NT-proBNP concentration in heart transplantation patients. Materials and methods The group studied consisted of 50 adult heart transplant patients. NT-proBNP concentration was measured in each patient 15 days after surgery to evaluate the prognostic value at 6 months follow up. Results The non-survivor patients showed higher NT-proBNP concentrations than survivors, with a median of NT-proBNP concentration on the 15 th day post-transplantation of 20632 ng/L (IIC: 6183 to 37925 ng/L) and 3923 ng/L (IIC: 1752 to 6890 ng/L) in the non-survivors and the survivors groups, respectively. The hazard ratio of mortality was 8.5 times higher (95% CI: 1.7 to 44.2) in those patients with NT-proBNP concentrations over 7500 ng/L on the 15 th day post-transplantation.
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