Abstract
Conventional immunofluorescence (IF) for kidney biopsies is generally performed on frozen sections and uses a panel of polyclonal antibodies directed against the constant regions of immunoglobulin heavy chains and light chains (LCs). Diagnosis of monoclonal gammopathy of renal significance (MGRS) currently relies on the detection of isotype and LC-restricted (monotypic) staining for heavy and LCs, supplemented by IgG subclass staining and paraffin IF in selected cases. Recently, Nasr et al.1 described the potential use of IF using polyclonal antibodies directed against the conformational epitope at the junction of the heavy and LC (HLC) constant regions (HLC-IF), including IgGκ, IgGλ, IgMκ, IgMλ, IgAκ, and IgAλ, for the evaluation of MGRS or other conditions with monotypic deposits.
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