Abstract
It is essential to identify high risk transient ischemic attack (TIA) patients. The previous study reported that the CSR (comprehensive stroke recurrence) model, a neuroimaging model, had a high predictive ability of recurrent stroke. The aims of this study were to validate the predictive value of CSR model in TIA patients and compare the predictive ability with ABCD3-I score. Data were analyzed from the prospective hospital-based database of patients with TIA which defined by the World Health Organization time-based criteria. The predictive outcome was stroke occurrence at 90 days. The receiver-operating characteristic (ROC) curves were plotted and the C statistics were calculated as a measure of predictive ability. Among 1186 eligible patients, the mean age was 57.28 ± 12.17 years, and 474 (40.0%) patients had positive diffusion-weighted imaging (DWI). There were 118 (9.9%) patients who had stroke within 90 days. In 1186 TIA patients, The C statistic of CSR model (0.754; 95% confidence interval [CI] 0.729–0.778) was similar with that of ABCD3-I score (0.717; 95% CI 0.691–0.743; Z = 1.400; P = 0.1616). In 474 TIA patients with positive DWI, C statistic of CSR model (0.725; 95% CI 0.683–0.765) was statistically higher than that of ABCD3-I score (0.626; 95% CI 0.581–0.670; Z = 2.294; P = 0.0245). The CSR model had good predictive value for assessing stroke risk after TIA, and it had a higher predictive value than ABCD3-I score for assessing stroke risk for TIA patients with positive DWI.
Highlights
It is essential to identify high risk transient ischemic attack (TIA) patients
Of all 1652 consecutive patients with a diagnosis of Transient ischemic attack (TIA), 457 patients with unavailable scores (286 with unavailable comprehensive stroke recurrence (CSR) score, 60 with unavailable ABCD3-I score, and 111 with unavailable CSR score and ABCD3-I score) and 9 patients lost to 90-day follow-up were excluded
In TIA patients with positive diffusion-weighted imaging (DWI), the final multivariate analysis showed that history of hypertension (HR 1.795; 95% confidence interval (CI) 1.094–2.945), history of stroke (HR 1.641; 95% CI 1.040–2.590), high A BCD3-I score (HR 1.181; 95% CI 1.058–1.319), and CSR score ≥ 4 (HR 3.075; 95% CI 1.942–4.868) were independent risk factors of stroke occurrence
Summary
It is essential to identify high risk transient ischemic attack (TIA) patients. The previous study reported that the CSR (comprehensive stroke recurrence) model, a neuroimaging model, had a high predictive ability of recurrent stroke. The aims of this study were to validate the predictive value of CSR model in TIA patients and compare the predictive ability with ABCD3-I score. In 474 TIA patients with positive DWI, C statistic of CSR model (0.725; 95% CI 0.683–0.765) was statistically higher than that of ABCD3-I score (0.626; 95% CI 0.581–0.670; Z = 2.294; P = 0.0245). Without more detailed imaging parameters, such as DWI pattern, the A BCD3-I score would have no good predictive ability of stroke in TIA patients with positive DWI. The aims of our study are: (1) validating the predictive value of the CSR model in TIA patients; (2) comparing the predictive ability of CSR model with A BCD3-I score
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
