Abstract
Motion analysis systems based on a single markerless RGB-D camera are more suitable for clinical practice than multi-camera marker-based reference systems. Nevertheless, the validity of RGB-D cameras for motor function assessment in some diseases affecting gait, such as Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP), is yet to be investigated. In this study, the agreement between the Kinect v2 and a reference system for obtaining spatiotemporal and kinematic gait parameters was evaluated in the context of TTR-FAP. 3-D body joint data provided by both systems were acquired from ten TTR-FAP symptomatic patients, while performing ten gait trials. For each gait cycle, we computed several spatiotemporal and kinematic gait parameters. We then determined, for each parameter, the Bland Altman’s bias and 95% limits of agreement, as well as the Pearson’s and concordance correlation coefficients, between systems. The obtained results show that an affordable, portable and non-invasive system based on an RGB-D camera can accurately obtain most of the studied gait parameters (excellent or good agreement for eleven spatiotemporal and one kinematic). This system can bring more objectivity to motor function assessment of polyneuropathy patients, potentially contributing to an improvement of TTR-FAP treatment and understanding, with great benefits to the patients’ quality of life.
Highlights
Human body movement offers physicians important clues on the progression of certain disabling disorders affecting movement, such as Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP).TTR-FAP is a highly incapacitating and inherited transthyretin amyloidosis, which has a wide range of clinical manifestations [1]
We evaluated the validity of an RGB-D camera-based system, against a reference motion capture system, for supporting clinical gait assessment of patients suffering from
Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP), a highly disabling condition frequently affecting gait, which is usually assessed through subjective observation
Summary
Human body movement offers physicians important clues on the progression of certain disabling disorders affecting movement, such as Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP).TTR-FAP is a highly incapacitating and inherited transthyretin amyloidosis, which has a wide range of clinical manifestations [1]. Human body movement offers physicians important clues on the progression of certain disabling disorders affecting movement, such as Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP). The reference systems for motion capture are systems that are able to accurately capture and track the movements of a given subject, by relying on multiple cameras and several retroreflective markers placed on the body [11]. These systems have been extensively used in the past for different applications, including clinical applications [12]. The provided 3-D joint data can be less accurate than those of reference systems [15], being important to evaluate its validity for each specific goal (e.g., gait assessment for a given disease)
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