Abstract
Throughout history, vaccines against infectious diseases have resulted in enormous benefits for humankind. Through their use, scourges of nature have been eradicated, controlled, or rendered irrelevant, and generations of children have survived into adulthood, unscathed by diseases that earlier in history would have been lethal. Vaccines harnessed the human immune system to its fullest extent long before the fundamental tenets of immunology were described; the concepts that form the basis of vaccine science have since been extended to a plethora of infectious and noninfectious diseases. The history of vaccination provides a window into the history of human scientific endeavor.
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