Vaccine immunization in children with primary immunodeficiency diseases

Abstract

Primary immunodeficiency diseases (PID)are a heterogeneous group of congenital and genetically determined conditions caused by one or more defects of innate and/or adaptive immunity, which are a common retarding factor of vaccines immunization.The infections, however, play a major role in the final prognosis of most PID.The immune response after the vaccine injection may be impaired in some PID cases, even no protection is evoked.Moreover, some disease caused by the live vaccine virus or bacteria strains could occur after immunization.The contents of this paper is to introduce the consensus of the vaccine immunization based on the category of PID, immunization of the contacts and other concerns. Key words: Primary immunodeficiency disease; Vaccine; Immunization; Child